rac-Rotigotine Hydrochloride

Name	rac-Rotigotine Hydrochloride
Synonyms	Rotigotine-d7 HCl N 0437 hydrochloride rac-Rotigotine Hydrochloride 5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]-1-naphthalenol Hydrochloride 1-Naphthalenol,5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-,hydrochloride
CAS	102120-99-0

Molecular Formula	C19H26ClNOS
Molar Mass	351.93384
Melting Point	>118°C (dec.)
Solubility	Acetone, DMSO, Methanol
Appearance	Solid
Color	White to Off-White
Storage Condition	Refrigerator
In vitro study	Rotigotine has a 10-fold selectivity for D3 (pK i =9.2) receptors compared with D2, D4 and D5 (pK i =8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pK i =7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC 50 respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (10 µM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 µM) slightly protects dopaminergic neurons against MPP+toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone. .

HS Code

2934990002

Last Update：2024-01-02 23:10:35

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rac-Rotigotine Hydrochloride

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